Replies to post #116645 on Anavex Life Sciences Corp (AVXL)

[polarbear77]

The Anavex train indeed Plex. Looks like they could be on track as well for Parkinson's trial readout in advance of Dr Francardo's presentation in May 2018 regarding a2-73 Parkinson's results.

Found her statements below to be fairly definitive and unambiguous re her testing to date. It seems the MJFF grant funds are being put to good use here.

GLTAL

Excerpted below from Dr Francardo [who is an independent researcher with grant funds from the Michael J. Foundation and has been studying the sigma-1 receptor for many years and publishing on the topic since at least 2011 (thanks again for pointing that out OFP)]:

"Using the same animal model of PD as in our previous study (i.e. intrastriatal 6-OHDA mouse model), we investigated the potential neurorestorative effects of ANAVEX 2-73, a compound with activity at both Sigma-1 and muscarinic receptors that is currently being tested in people affected by Alzheimer´s disease. Our results reveal that ANAVEX 2-73 is able to ameliorate parkinsonian motor symptoms in tests assessing spontaneous rotational activity and forelimb use asymmetry, and exerts neuroprotective/neurorestorative effects on the nigrostriatal dopamine system."

https://www.michaeljfox.org/foundation/researchers.php?id=1841
Veronica Francardo, PhD
Assistant Professor, Department of Experimental Medical Science BMC F11 at Lund University
Location: Lund, Sweden

Veronica Francardo received her undergraduate training at the University of Trieste, Italy, where she graduated in Medical Biotechnologies. Since 2007, Veronica is a researcher at Lund University, Sweden, where she obtained her PhD degree in Neurobiology under the supervision of Prof Angela Cenci-Nilsson. Veronica Francardo is currently Assistant Professor in the group of Prof. Angela Cenci-Nilsson and carries out pre-clinical research on animal models of Parkinson’s disease and post-mortem human brain tissue. The main interest of her work is to test and develop potential new therapies for Parkinson’s disease and related disorders."

[123tom]

I hope so too...


but I've learned to trust the chart and be cautious. with volatile and manipulated small biotech plays.
I like the science, and see no fundamental reason for the take down from 5.50 to 3.33.
but it was achieved. financial manipulation games. I can accept it. but it means Caution must be maintained at all times in my view. for me it means giving up on hoping for rallies before they happen, hoping for great news yet to come and when it comes , what usually happens.... wall street games . I just watch the chart . and expect more games, and volatility in both directions.
Right now, those who bought at 3.33-3.80 looks like it was pretty good. it makes buying now at 4.00-4.10 look ok. and that's all there is to say right now. Resistance overhead from 4.50-5.00 is in play now. to watch and see what it does. how strong will AVXL be to climb thru it. this is a real test now for AVXL to show whether this rally will be true or not. yes it has run from the 3.33 bottom , 1.20 already. but the support zone needs to hold 4.20-4.10 and did so today, so far so good. but its only the first test of 4.20 . there should be more to come .but yes,a good show of strength in the morning to hold 4.20.

its a fair start now for a recovery. took all this time,just to finish this first part, a first rally wave.however high it runs now, after this rally comes a Pullback,that will be the next test after resistance stops the rally. or else the next test might be what wall street does with the September "news cycle" do you anticipate any slam down, like we've had before? I do. I think you have to . so we're not out of any woods just yet,in my view. the support base 3.90-4.30 has to become strong....just like it had to many months ago,. but recently failed. thats the wall street game. always a wall street game to deal with..