R:....I believe Vytorin, which is a combo drug combining a statin with Zetia, had an RRR of 7% as measured in the Improve IT study and even that low an RRR attracted a lot of interest from Docs...Nevertheless, R-IT has a stated RRR of 15% in order to be regarded as a success.... and I believe that it would take a R-IT RRR of 30% to be considered overwhelming.