Just because I like to bounce cardio stuff off of you, have you looked at the recently public BOLD's GT approach to treat Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT)? They are specifically targeting CASQ2-related CPVT and trying to achieve long-term expression of calsequestrin 2 in cardiac muscle cells. They claim that by restoring CASQ2 protein levels, the heart is able to maintain a normal heartbeat rhythm. See: http://www.audentestx.com/at307/ .
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