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Re: poorgradstudent post# 211369

Tuesday, 07/11/2017 7:28:19 PM

Tuesday, July 11, 2017 7:28:19 PM

Post# of 257367
BOLD - AT307 for CPVT

Just because I like to bounce cardio stuff off of you, have you looked at the recently public BOLD's GT approach to treat Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT)? They are specifically targeting CASQ2-related CPVT and trying to achieve long-term expression of calsequestrin 2 in cardiac muscle cells. They claim that by restoring CASQ2 protein levels, the heart is able to maintain a normal heartbeat rhythm. See: http://www.audentestx.com/at307/ .

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