Replies to post #1246 on Synaptogenix Inc (SNPX)

[drbio45]

bryostatin restores the synaptic networks which is the cause of alzheimers

LUVOX or Fluvoxamine is an approved Sigma-1 Receptor Agonist. That is the target for Anavex's drug. Why hasn't LUVOX been tried in Alzheimer's?

[SF Wolf]

blu, I think you should qualify your statement: “The problem with Neurotrope is that it doesn't address the cause of Alzheimer’s, which is accumulated oxidative stress”

First, it is your opinion is it not? And where is the research to prove your hypothesis?

Also, how does your idea account for families that have a clear genetic component for early onset Alzheimer’s?

[F1ash]

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"The problem with Neurotrope is that is doesn't address the cause of Alzeimers, ...."
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I strongly suggest that you view (or review) the following presentation.

https://www.veracast.com/webcasts/bio/ceoinvestor2017/18111483071.cfm?0.593469021981


They weren't even targeting plaques, their removal was an unexpected result. Perhaps this approach will reveal the " missing link" behind the root causes of A-beta and Tau that is truly the correct upstream target.

"Neurotrope Bioscience’s lead Alzheimer’s drug candidate, bryostatin, promotes the formation of new synapses in the brains of mice, according to the study, “PKC epsilon Promotes Synaptogenesis through Membrane accumulation of the Postsynaptic Density Protein PSD-95,” recently published in the Journal of Biological Chemistry."

https://alzheimersnewstoday.com/2016/07/05/neurotrope-announces-new-study-published-journal-biological-chemistry-shows-bryostatin-pkc-epsilon-activator-generates-new-synapses-accumulation-synaptic-anch/