Rett is a rare disease so finding right patients at place is not an easy task. They need 60 patients and trial duration is 12 weeks (3 months)
This means - the end of the year timeline may prove to be optimistic - for this to happen - the last patient needs to be enrolled before Aug - give one month for topline result calculations/ preparation.
The trial has not started yet - assuming the trial starts by Mid-March and 1st patient is enrolled in April - they will need to enroll 12 patients per month
This number is high for a rare disease trial enrollment and is aggressive. (They will also compete with other trials for patients)
So if we get topline results by end of year - it is very good sign.
We just need to confirm that protocol is approved and trial is registered and officially started.