No doubt AVXL can be worth $8B+ if it works on everything (I hope it does).
I'm basing my $3B on the notion that Biogen will see early success and make a jump to buy AVXL before the other indications (AZ, Rhett, Pakinsons) play out. The Rhett and Parkinsons will be short studies (12 weeks). It may take another 12 weeks to kick it off so I'm thinking Biogen will see the outcome of their testing in the coming weeks or month and make their move then (before we see/hear the results of the other indications). I suspect we won't hear the results of the Rhetts and Parkinsons study until July.