In a blind retrospective study carried out in accordance with guidelines for reporting of tumor marker studies (REMARK) [15] and standards for reporting diagnostic test accuracy (STARD) [16], we show that the presence of PS in blood accurately detects ovarian cancers and differentiates between patients with benign and malignant disease. These data suggest that the presence of PS in patient blood is diagnostic for cancer.
Do exosomes contain DNA that can be traced to the cancerous organ?
"we show for the first time the presence of dsDNA in exosomes representing the whole genomic DNA. Our finding that exoDNA can be used to identify mutations present in parental tumor cells illustrates its significant translational potential as a circulating biomarker for cancer in the clinic. ExoDNA is an attractive, potential biomarker candidate in the early detection of cancers and the monitoring of treatment response for several reasons: its protection and thus inherent stability within exosomes; the possibility to isolate or enrich tumor-derived exosomes in complex plasma samples via exosomal surface markers; and its easy and fast preparation." Cell Research http://www.nature.com/cr/journal/v24/n6/full/cr201444a.html