Replies to post #185779 on Avid Bioservices Inc (CDMO)

[Carboat]

And you also thought the Pancreatic results were going to be stellar.

[biopharm]

Since proteomics, I assume, will be the reason for the better understanding of the MOA of Bavituximab/PS Targeting -- I am going to add this video from Dr. Patrick Soon-Shiong

Excellent Video and should watch, especially if many want to understand the "MOA" or better understanding of the MOA of Bavi/PS Targeting when Peregrine gets time to explain it to us. Must be top secret clearance that many in the military don't think landscapers can figure out : )

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7:30 - Intro

8:24 - From DNA to RNA to protein to Peptide (Protein Receptors..)

9:45 - Pancreatic Cancer patient case... re: Gemcitabine and how response rate was 0%. Found this section interesting... as Gem.+Abraxane just approved in UK yesterday for Pancreatic Cancer...

11:00 - "Impossible Today for Clinical Oncologists To Keep Up With Science of Medicine in Real Time..."

11:38 - Maximum tolerated Dose

12:00 - relative of Soon-Shiong...Metastatic Pancreatic Cancer and Soon-Shiong speaking with oncologist telling treatment is wrong...

15:00 - Albumin / NASA .. losing weight during cancer...

17:40 - .. you don't inherit cancer, you inherit the "risk"...

20:00 - Breaking down the Math...

24:00 - DNA (22,000 Genes) to RNA (200,000) to Protein Pathway (2 Million Proteins) to Protein Receptors (10,000 Networks)

24:50 - "Proteins tell you where you are.... in the state of disease(cancer) >>>> blood tests are coming I say.... : )

26:40 - Biopsy ... gene/protein views at the same time...

27:30 - Liquid Biopsy ... see whats driving the tumor in real time (this was my question basically to you, GJH.... in regards to if there is a way to record longterm..etc while injected with a PS Targeting drug such as Bavi..etc..)

31:20 "Poisons we have been using for 50 years"

32:35 (think back of Dr. Stopek) ... "CTC" Circulating tumor cells leading us back to physics which I believe CP knows something about.... : )

CTC's > back to extracting CTC from the blood... analyze... treat cancer like diabetes....

32:50 - Question/Answer Period...

36:50 - Hurdles... one being Regulatory

39:00 - 50% of mutated Genes do nothing... ( my analogy: about 1/3 of us have ruptured discs and does not do anthing to us, unless the smaller percentage that hit a nerve...)

40:00 - In London, there is an entire city that is part of a proteomic profiling full scale clinical trial

40:45 - Listen here...

41:30 - Dr. Patrick Soon-Shiong mentions launching a collaboration with Celgene re: every clinical trial will involve proteomic profilng ( He also mentioned he talks(ed) with GSK and Novartis...

42:35 - Cancer will be re-classified

46:20 - ... lots of industries will be changing

49:00 - "City of Hope" building a gmp lab inside hospital

50:30 - new patent that Soon-Shiong talks about that he received

52:00 - Quantum Change ... need to look at the proteomic level and see what is changing... ( again, GJH, this is the question I was asking about if this can be monitored/recorded longterm after a PS Targeting drug such as Bavi is injected "AND" if this data may be used to even get a drug approved by the FDA or at the minimum in conjunction with a smaller trial and/or used in proving its MOA and possibly a Data Monitoring Committee can use this data when deciding to stop a trial

52:50 - The War Against Cancer is the War Against Time

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Overall, great video for the hour and it will certainly help many here understand the better understanding of the MOA of Bavi when Peregrine gets time to explain it to us : )

[goodJohnhunting]

GJH.... a quick question if I may-- is this normal in a lab environment where one video-record the cellular level and exactly what changes are happening ?

Yes, more recently a hyperspectral microscope would do it.

And btw, a Cotara + Crestor combo could be a super effective therapeutic in GBM, IMO..

Another revelation

All the best,
John