The invention in LLY's Alimta patent that held up in court consists of dosing Alimta with folate and vitamin B12 to reduce toxicity: http://patft.uspto.gov/netacgi/nph-Parser?Sect1=PTO1&Sect2=HITOFF&d=PALL&p=1&u=%2Fnetahtml%2FPTO%2Fsrchnum.htm&r=1&f=G&l=50&s1=7772209.PN.&OS=PN/7772209&RS=PN/7772209