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Re: Summer2762 post# 176054

Wednesday, 03/26/2014 10:38:21 PM

Wednesday, March 26, 2014 10:38:21 PM

Post# of 257475
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Similarly we do not know whether cabazitaxel hit its required significance level at interim or DMC was worried about AEs and recommended continuation.



I agree with JQ - the HR on the OS was nowhere near constant. E.g. Much(!) better HR in the second half than in the first.

As a bull argument it is not unreasonable to assume that effect is a characteristic of the drug - and thus your comment is valid. But nonetheless I'd still be cautious.

FWIW.

Clark

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