From Pearl I (450+267) we know that the SVR12 for GT1b naive is 95%. From Sapphire I (450+267+333+Rib) we know that the SVR12 for GT1b naive is 98%. Therefore the SVR12 for GT1b naive for Pearl III (450+267+333) must be between 95-98%. The figures for GT1b treatment (Pearl II) must be between 90% and 97%. Are this thinking too simple?