Success in SAPHIRE-1 was largely expected. Efficacy of the 3-DAA + ribavirin regimen was known to be strong from the phase-2 AVIATOR study and the main question in SAPHIRE-1 was whether a newfound safety problem would surface. (It didn’t.)
ENTA’s stock will react more positively to strong data in the PEARL-2/3/4 studies if the arms without ribavirin perform as well as—or nearly as well as—the arms with ribavirin.
“The efficient-market hypothesis may be the foremost piece of B.S. ever promulgated in any area of human knowledge!”