I liked what you wrote but I will have to disagree with needing more than 10. You might ask why??? Simply because this is only a phase 1 trial!
The majority of biotechs start off phase 1 with a small sample size 10 to 20 just to test the efficacy and safety slightly. Once it gets to phase 2 then they enroll 100 to 150 and then in phase 3 normally there is 300 or more patients enrolled. It's always been like this. It is not uncommon for phase 1 to only have 10 patients as a sample size!