It's all about revenue's like any other stock. A lot of the penny plays are purely speculatory and full of what "May" come or "Expected" revenue's, just like you see with GYST. The companies that actually start to turn a profit are the one's that break into pennies and dollars. Without revenue, the companies have no choice but to search for money elsewhere, whether that be loans or additional shares being added to the float. Not good! Unfortunately, a large percentage of sub penny stocks fall into this category IMO