Synergy Pharmaceuticals (SGYP) announced that on Oct 19, 2012 the co initiated oral dosing of healthy adult volunteers in a Phase I clinical trial of SP-333, a guanylate cyclase C (GC-C) agonist designed to treat ulcerative colitis. http://finance.yahoo.com/news/synergy-pharmaceuticals-initiates-dosing-healthy-100000379.html