I have completely followed the discussion. I was noticing that the talk is on inhibiting p38 but I never see a mention of whether the inhibition is against all isoforms or not (maybe it is presumed all?). For what its worth Pirfenidone is thought to inhibit I believe just p38 gamma. While its not a completely safe drug its side effects are manageable (GI and phototoxicity) and I don't recall coming across and QTc issues.