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Re: biomaven0 post# 147081

Thursday, 08/16/2012 5:38:39 PM

Thursday, August 16, 2012 5:38:39 PM

Post# of 257437

The safety issues have been all over the place - hard to know if they are class effects or (perhaps more likely) because most of the molecules were built off the same scaffold if I recall correctly.

This probably doesn't advance the discussion much, but, per its 10-K filed today, ARRY disclosed:

"Compared to other p38 inhibitors, ARRY-797 has distinct properties: it is highly selective, has exceptional potency in whole blood samples, has a differentiated pharmacokinetic profile and is highly water soluble."

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