ODAC accepted the story of Marqibo’s potential to get
responses that could allow patients to move on to transplantation.
“I felt that this drug was able to convert the patients who
were in a palliative setting to a potentially curative setting,” said ODAC member Mikkael Sekeres, associate professor of medicine at the Cleveland Clinic Taussig Cancer Institute Department of
Hematologic Oncology and Blood Disorders, at the meeting March 21. “That’s a meaningful change in goals of therapy for patients.”
These responses were seen in a 65-patient study. Five of
the patients who responded moved on to transplantation, and, for
two of them, the transplants were beneficial.