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Spectrum Pharmaceuticals completes a Phase III trial in Non-Hodgkin's Lymphoma in Elderly Patients
https://adisinsight.springer.com/drugs/800009004
Last Update Posted 2024-04-26
https://clinicaltrials.gov/study/NCT01478542
Study results have not been submitted
Research on the loading and release kinetics of the vincristine sulfate liposomes and its anti-breast cancer activity
https://www.sciencedirect.com/science/article/pii/S2590156724000306
"VCRS liposomes also enhanced in vitro and in vivo antitumor activity. Thus, VCRS liposomes showed great potential for VCRS delivery, and the loading and release kinetics were well researched to provide a reference for investigating active drug loading liposomes."
"The prescription and process were optimized based on the patent of Marqibo®(Sarris et al., 2011; Webb et al., 1996)."
We all know that is legal or illegal for our brokers taking /removing our stock ( symbols) from our portfolios… for some reasons like Untrade-able stocks..but our TLON waiting for CVRs (valid 15-20 years period from M&A date ) Coming for TLON stock Holders…we knew it that we cannot trade TLON
We don’t know exactly our brokers Now putting our TLON CVRs in Dormant accounts temporarily or Removing them completely ( Losing our money completely?)
We all should file Class Actions Lawsuit??
All TLON CVRs Holders please share your updated information about our CVRs here
Happy Thanksgiving and God bless you all
Td Ameritrade took it off from my account back in Aug and is gone. I argue nothing happen they took it off
Hello All TLON investors
How have you been so far for long waiting our CVRs coming already or soon ???
We know that Our TLON CVRs have been in Dormant Accounts from our Brokers… but your CVRs have still been on your portfolios or your brokers took off CVRs from your portfolios? Our broker ( Etrade) took our CVRs off from our portfolios because of Not Tradable/ Transferable??
Operating_line and other TLON CVRs holders share your info here so we can help each other ??????
We all look forward to hearing from your sharing CVRs Information…
Happy Thanksgivings, Merry Christmas and Happy New Year??????
We appreciate your responses
we all TLON CRV holders pray for good results with our long waiting money coming soon
God bless all TLON CRV Holders now
I think the Talon rights should remain at DTC, not Equiniti, unless there is some announcement. I do not know how Wells Fargo are involved or what exactly 'in charge of TLON CVRs' means in this context.
I thought Equiniti are the transfer agent for the CVRs because they acquired corporate stock transfer and I confirmed this with them in late 2020. That means all the CVRs were brought over to the Equiniti system without changing who owns the CVRs.
I contacted my old broker who said the TLON CVRs are still held dormant there. I could not move them to my new broker since they are non-tradeable securities. According to my understanding, if there is ever a payout on the CVRs, then the milestone payment should enter a cash account held for that dormant account.
Crossing my fingers that some of those milestones are hit in the coming years...
Latest from CASI Pharmaceuticals
"The Company also has greater China rights to ZEVALIN® (Ibritumomab Tiuxetan) and MARQIBO® (vincristine sulfate LIPOSOME injection), each of which is approved in the United States by the FDA for specified indications. Due to the evolving standard of care environment, the rare and niche indication for these products, and the Company’s commitment to prioritize resources, the Company is currently evaluating its options for these products."
https://www.streetinsider.com/SEC+Filings/Form+424B5+CASI+Pharmaceuticals%2C/19130686.html
FDA’s accelerated approval program: Is change on the way?
"The FDA has also been revisiting cancer therapy approvals made through the program. In April 2021, the agency convened the Oncologic Drugs Advisory Committee (ODAC) to review six so-called dangling accelerated approvals in which the confirmatory trials had failed but the drug remained on the market. Of the six checkpoint inhibitor indications reviewed, ODAC recommended that four be maintained (RELATED: ODAC recommends pulling 2 of 6 accelerated approvals, Regulatory Focus 30 April 2021).
The committee is scheduled to meet again on 2 December to review dangling accelerated approvals for Farydak (panobinostat) for multiple myeloma and Marqibo (vincristine sulfate liposome injection) for adults with Philadelphia chromosome negative acute lymphoblastic leukemia. Novartis received accelerated approval for the multiple myeloma indication in 2014, and Talon Therapeutics’ Marquibo got its accelerated approval nod in 2012."
https://www.raps.org/news-and-articles/news-articles/2021/10/fdas-ccelerated-approval-program-is-change-on-the
Hello to all CVRs Holders of our Hard Earned Money in TLON
We would like to know any one of us heard and Received any money from Our CVRs of TLON ??
We haven’t received or heard any updates from our brokers or anyone else yet ???!!!!
If anyone of us holders of TLON CVRs have any updates, please share them here with all of us ??????
We are really grateful to good news for our CVRs ( good for 20 years from 2015 ) from Spectrum pharmaceutical, and any person ??????
Thanks
Hello Tlon investors
How are you? We are so Silent !!!???
Any Tlon investors have any updates about our CVRs so far?
Please if you have any updates, share it here
Thanks
Hi Operating-line
I spoke with our Etrade broker ... they said it will take several weeks ....??to find out our CVRs... I talked to different people: Spectrum pharmaceuticals ( who bought TLON therapeutics) , Computershare( transfer agency of Spectrum) , Wellfargo ( computershare said Wellfargo is in charge of TLON CVRs)
Equinity said they are not in charge of TLON CVRs...
We all TLON shareholders pray to God’s Blessings and Protections ??????
Any TLON shareholders know Well about Financial Statements ( earnings reports...) so you can read earnings statements of Warburg, ...who were also shareholders of TLON therapeutics too.... if they have Already Received TLON CVRs... why not us ??
Equiniti Acquires Corporate Stock Transfer To Expand In US
04 November 2019
https://equiniti.com/uk/news-and-views/news-releases/equiniti-acquires-corporate-stock-transfer-to-expand-in-us/
You can show that link to whoever you are communicating with on this
Hi Operating Line
How are you? We just call Equinity at 800-401-1957 to ask them about TLON CVRs... she said they don’t see my account in their system staring with 4..... or 3.... I said I don’t know what account you are talking about??? I gave her my E*TRADE account, My DOB, My SS...she said she see it ??
I go online EQ shareowneronline, I tried to registered for Online Access... the web asked my authentication ID( 12 digit numbers) or my account?? I don’t either...
I am not sure when Equinity Acquired Corporate Stock Transfer... they would send our TLON shareholders Authentication ID associated with our shares of TLON ... but we missed it ???
We called E*TRADE... they still not know that TLON shareholders have had Equinity Trust Company for our CVRs ???? We gave them Equinity phone numbers....They said they will call them and find out ...it is really Smelling very Bad for E*TRADE??? They haven’t Restored our TLON shares on our E*TRADE accounts Yet either???
Please all TLON shareholders are here to share your cases with your brokers .... so we can fight together for our hard earned money from our TLON CVRs....
All for one and one for all
God bless our all TLON shareholders ?????
Any Tlon investors heard/ saw any our CVRs coming yet since year 2021 ??Please share here????
We pray to God’s mercies ??
Okay. Let us know if you succeed to get the CVRs back.
Hopefully TDA will cooperate and we will see a payout in the coming years
"Vincristine Sulfate Liposome Injection Drugs Market Set to Register robust CAGR During 2020-2025"
https://www.groundalerts.com/vincristine-sulfate-liposome-injection-drugs-market
There are recent discussions on using vincristine sulfate for treatment protocol.
"The Food and Drug Administration (FDA) has issued a safety alert regarding the preparation of vinca alkaloids.
According to the Agency, these chemotherapy agents, which include vincristine sulfate injection, vinblastine sulfate injection, and vinorelbine tartrate injection, should only be prepared in intravenous (IV) infusion bags. In order to reduce the potential for unintended intrathecal administration, the FDA is working with manufacturers to update the drug labeling to remove instructions for preparation of these agents by syringe."
https://www.cancertherapyadvisor.com/home/cancer-topics/general-oncology/vinca-alkaloids-fda-safety-alert-intravenous-infusion-bags-prep/
Hi Operating Line
Thank you for your information. I will reach out to my broker TDA. I bought Talon through scottrade but you know all these companies buy each other.
I'm going to request to get them back. Just sucks I have to remember the number of CVRs I had. I have find that number.
Thanks again!
I think if you do not have you CVRs in your account, please get the written explanation from your broker and forward that to Equiniti. It cannot be your CVRs are just taken without an explanation given to you.
You need to discuss the facts of what has happened to your account with operations since they can study the problem you are facing, if your broker has not helped you so far.
https://equiniti.com/us/contact-us/
As I understand from Equiniti, no payout occurred yet and there has been no change to the CVRs with the rights still at DTC. Any change to that would require a public notification.
Happy new year
Happy New Year ??????
We would like to know any TLON investors received your CVRs yet
God bless our TLON shareholders ????
Happy New Year ??????
We would like to know any TLON investors received your CVRs yet
God bless our TLON shareholders ????
As mentioned, no payout for TLON CVRs has occurred according to Equiniti. No I cannot share Equiniti email. There is nothing to stop your broker confirm with Equiniti operations department, as I did and sort this out. You need some confirmation in writing from your broker on the reason for removal and demand the CVRs are returned.
Hello Operating
How are you? We would like to know that you or any TLON shareholders here have Received Yet any penny for our CVRs since Spectrum bought out TLON .... please share here with all TLON shareholders ??????
Operating, please share here with us what email and or phone number of Equiniti you communicated with them ? If you don’t mind so you can share here so we can use them to communicate with Equiniti and our brokers too????
We greatly appreciate your sharing with all TLON shareholders here
Thanks again ??
this is back to you. please add pressure back to resolve between broker and DTC and request written clarification on the removal of your TLON CVR position, if needed.
I just got a response. There should be no problem and the positions should not be removed from the owners.
Equiniti confirmed the Talon rights are still at DTC and will remain so until notified.
Basically, there was a one to one mapping for positions under corporate stock transfer to equiniti with no change in any ownership and this should remain the same.
In other words, your broker needs to consult with DTC and it should be confirmed between them. Otherwise, get broker to contact Equiniti to confirm. We should still have our TLON CVRs with potential for a payout according to terms of milestones being hit !!!
Thanks
If any TLON investors have any update about Our CVRs, please share here ??we can fight each other for our hard earned money investing in Tlon ??????
Thanks again
No response.
I see I wrote on October 10th and so one month wait.
I just emailed again to try obtain a response even though it can take time to find out what is the status.
Hello operating line
How are you? You got their responses yet? Please share
Thanks
Thanks sir
Please share It here When you got their responses
Every TLON shareholders if we have any info about our CVRs, please share it too please ?????????
yes, they absorbed the agent that handled the TLON CVRs originally and it is confirmed in the weblink that I shared.
As mentioned, Equiniti is the successor agent.
Equinity now should have all docs related to M&A agreements between TLON and Spectrum??
CST is now part of Equiniti
"Equiniti Group plc (“Equiniti” or “the Group”), an international technology-led services and payments specialist, announces that it has completed the acquisition of Corporate Stock Transfer, Inc. (“CST”). CST will become part of Equiniti’s US division, EQ."
https://equiniti.com/uk/news-and-views/news-releases/equiniti-acquires-corporate-stock-transfer-to-expand-in-us/
Corporate Stock Transfer inc. was first our Transferring Agent , right? So they knew exactly how much we all TLON shareholders received for per share ?
I will update if any response from Equiniti.
You misunderstood. Corporate Stock Transfer, Inc. has been acquired by Equiniti Trust Company.
We all TLON shareholders should Call Transfering Agent ( Corporate Stock Transfer ,inc, (303) 282-4800 ) to Verify that we should Receive $0.1 or $0.05 per share for Final Prices of Last Trade on M&A Agreements?
Operating- line please share with after you receive any responses from Equinity guys?
I think it was 0.05 per share. I would remember if there was a mistake at the time. I think the cash part was relatively small at the time that Spectrum acquired Talon and the cash was correctly received in my brokerage account.
For Equiniti, lets wait to see if they respond within 2 or 3 weeks.
The company website is: www.equiniti.com
If I hear anything useful, I will share it.
If the issue is with the agent not communicating with DTCC, the successor agent should sort it out.
We would like to know when M&A agreements finished , how much each share of TLON was worth of ( $0.05 or $0.1 ) when you received? ???
On M&A agreements said that they would give TLON shareholders By the final price of the final trade on final day of M&A agreements???
We saw $0.1 for Final Price of the Final day ??? But we received Only $0.05 per share for final day?? Is that right for all of you too when you received $0.05 per share or $ 0.1 per share as we saw on the broker flag form ( $0.1 per share)
Please all TLON shareholders share here what you Saw and received for per share from your brokers???
Operating _line pleas know results After you contacted / sent message to Equinity ??????do you have their phone number? Email? Person of contact? Please share here so each of TLON shareholders can do our parts and share here to have our CVRs that we worked hard to earn it ??????
Thanks all TLON shareholders here ????????
It appears from your message that the CVRs may have been cancelled withtout any instruction from the agents after the acquisition. I just left a note with Equiniti (successor agent) to contact DTCC and clarify the situation. Lets see if they can help get them restored. The other route is to try contact Spectrum/Acrotech/CASI investor relations to see if they can assist.
We talked to manager Travis Carroll ( 800-661-4587)who said we would wait for him to contact DTCC then he would call back... he never called back ... like we did call in several times and talked to different guys... they said Carroll would call back ...
We said we called SEC to complain about their Unlawful Bussiness Practices/ Security Frauds...
Finally we had a heated discussions with Carroll. He said that is the way DTCC does business when TLON does not a transferring agents ???
Any one here have accounts with E*TRADE? Please contact Travis and find out ???
How about other brokers?? Fidelity? Charles Swab??...
Please share here so we can do together to Prevent cheating and recover our CVRs for our hard earned moneys ????
yes, please try that way first.
Let me know if it works.
Thanks,
We may call and talk to E*TRADE again about Equiniti, a new agent ... to see how they answer ??