Why couldn’t (shouldn’t) a futility test be based on a linear combination of: i) the a posteriori power of the trial based on the actual data to date and the original powering assumption for the data yet to be reported; and ii) the a posteriori power of the trial based on the actual data to date and the assumption that the data yet to be reported are consistent with the data to date?
“The efficient-market hypothesis may be the foremost piece of B.S. ever promulgated in any area of human knowledge!”