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Re: mcbio post# 131157

Tuesday, 11/15/2011 9:53:00 PM

Tuesday, November 15, 2011 9:53:00 PM

Post# of 257285
Well MDV3100 in early stage trials (at a higher dose) had a couple of seizures reported as SAEs. Even a low seizure incidence might seriously hamper its commercial prospects compared with Zytiga - not saying it should do so given the know long-term adverse effects of steroids, but I think it would.

Note the steroid dose for Zytiga is pretty small, but I think it is enough to make doctors think twice if they have a comparable steroid-free alternative.

Peter

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