Biotech Values

[genisi]

Do you think we will see Peg/Riba used at all with these drugs in late stage testing?

No doubt that eliminating Peg/Riba is what VRUS is aiming to and they are testing the limits of the different regimens by taking interferon first out of the game and then Riba. I do think we'll see Peg/Riba sparing regimens in these drugs in late stage trials. In the sweet spot of GT2/3 population, I even see a chance for a nuke monotherapy to be good enough. Don't know if adding Riba to PSI-7977 in the QUANTUM trial is just to show Riba only adds AE's and/or tolerability issues, they might think PSI-7977 mono isn't enough in GT1. Anyway, interferons will be the first to go and the question is which all-oral combo to which population. Nukes will definitely be there.