Dacomitinib (a/k/a PF-00299804) is PFE’s HER-1/2/4 inhibitor for NSCLC. It is in phase-3 trials in the first-line metastatic setting (for patients who received Tarceva in the adjuvant setting) and the second-line metastatic setting (for patients who received chemo in the first line); results are expected in 2012 and 2013, respectively: