InvestorsHub Logo
Boards
News
Market Data
Markets
Discover
Discover
Subscribe Login/Register
S&P 500
5,487.03
(
0.25%
)
US TECH 100
19,430.40
(
0.14%
)
Dow Jones
38,834.86
(
0.15%
)
Brent Oil
84.92
(
0.15%
)
Bitcoin
65,201.16
(
0.10%
)
Post# of 252254
Next 10
Reply Private New
Public Reply Private Reply New Post
Keep Last Read
Keep Next 10 Report Keyboard Shortcuts
Next 10 Prev Next

genisi

Send PM Follow Ignore
Followers 29
Posts 5148
Boards Moderated 0
Alias Born 05/24/2006

genisi

Re: mcbio post# 124035

Thursday, 07/28/2011 5:14:37 AM

Thursday, July 28, 2011 5:14:37 AM

Post# of 252254
I think ß-secretase inhibitors therapies will face similar challenges to those seen with y-secretase (because the enzyme has many substrates* and a wide substrate binding domain) I'd expect serious off-target tox.

*like neuregulin-1, which is involved in myelination and y-secretase inhibitors have in fact shown AE on myelin in animal models.
Public Reply Private Reply New Post
Keep Last Read
Keep Last Read Next 10 Report Keyboard Shortcuts
Next 10 Prev Next

Join the InvestorsHub Community

Register for free to join our community of investors and share your ideas. You will also get access to streaming quotes, interactive charts, trades, portfolio, live options flow and more tools.

Sign Up