It's all very puzzling. With the gamma secretase news, maybe amyloid as a protective response is starting to look more plausible. I guess that would leave tau as the next batter up.
What about the beta secretase inhibitors? What's the latest on them? I know LGND has one in Phase 1 partnered with MRK via their prior acquisition of Pharmacopeia. I take it the point of them is still to try to prevent amyloid production and overall point being that this may not be the best approach.
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