Replies to post #124035 on Biotech Values

[ghmm]

I seem to recall that being a much longer trial aimed at addressing the disease earlier on. Don't recall exactly by memory (and too lazy too check :-)) but think length is in YEARS.

[biomaven0]

Don't know much about BACE inhibitors. There was this warning some years back - don't know what the updated story is:

http://pipeline.corante.com/archives/2007/05/17/betasecretase_not_so_fast.php

Peter

[genisi]

I think ß-secretase inhibitors therapies will face similar challenges to those seen with y-secretase (because the enzyme has many substrates* and a wide substrate binding domain) I'd expect serious off-target tox.

*like neuregulin-1, which is involved in myelination and y-secretase inhibitors have in fact shown AE on myelin in animal models.