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Re: DewDiligence post# 122226

Wednesday, 07/13/2011 11:18:14 AM

Wednesday, July 13, 2011 11:18:14 AM

Post# of 257268

Unfortunately, no. The slide you cited makes it very clear that BCX5191 is a nucleoside, not a nucleotide. Such a design is obsolete (remember IDIX’s NM283?); I doubt that BCX5191 will make it into clinical trials.





It looks like Tibotec/Medavir are also working on a nucleoside inhibitor



http://viralmatters.blogspot.com/2011/06/medivirtibotecs-ns5b-inhibitor.html



Whether there's some unforeseen merit to the idea remains to be seen. Perhaps there's some IP licensing issues on HCV nucleotides which is moving the industry in this direction?


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