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Re: flatlander_60048 post# 122223

Thursday, 06/23/2011 11:48:45 PM

Thursday, June 23, 2011 11:48:45 PM

Post# of 257268

BCRX—slide 20 from my earlier post indicates that the their nucleoside is capable of "Rapid and efficient conversion to the triphosphate form and long triphosphate form half-life in human hepatocytes." Does this make it any more viable?

Unfortunately, no. The slide you cited makes it very clear that BCX5191 is a nucleoside, not a nucleotide. Such a design is obsolete (remember IDIX’s NM283?); I doubt that BCX5191 will make it into clinical trials. Regards, Dew

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