BCRX—slide 20 from my earlier post indicates that the their nucleoside is capable of "Rapid and efficient conversion to the triphosphate form and long triphosphate form half-life in human hepatocytes." Does this make it any more viable?
Unfortunately, no. The slide you cited makes it very clear that BCX5191 is a nucleoside, not a nucleotide. Such a design is obsolete (remember IDIX’s NM283?); I doubt that BCX5191 will make it into clinical trials. Regards, Dew
“The efficient-market hypothesis may be the foremost piece of B.S. ever promulgated in any area of human knowledge!”