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biomaven0

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biomaven0

Re: genisi post# 118805

Monday, 04/25/2011 4:18:29 PM

Monday, April 25, 2011 4:18:29 PM

Post# of 252443

dimethyl fumarate is rapidly converted in vivo to monomethyl fumarate



Yes, and the monomethyl form is actually the active moiety. So I'm assuming the monomethyl form is not orally absorbed well.

Strangely enough, dimethyl fumarate is used as a desiccant and anti-mold agent in the packaging of various consumer items. Unfortunately it's also a contact allergen for some folks, leading to strange publications such as the following:

Contact Dermatitis. 2011 Jan;64(1):58-9. doi: 10.1111/j.1600-0536.2010.01782.x.
Leucoderma after Chinese sofa dermatitis.
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