Biotech Values

[mcbio]

NKTR-118 vs. Relistor (rapid onset)

If your hoping for a negative (sorry I am not ) NKTR hasn't tested the 12.5mg dose and 5 only showed a trend but 25mg was very efficacious.

Just to add to our discussion before in comparing NKTR-118 to Relistor. There's an interesting post on PGNX's YMB from yesterday where a poster (play_4_less) talks about subQ Relistor having an onset of action of between just 20 to 25 minutes with the hope of oral Relistor, which is in ongoing Phase 3 trials, having a similar rapid onset of action. The poster then notes that NKTR-118 in its 25mg dose (which is the highest dose that is going to be tested in Phase 3) had a median onset of action of 6.6 hours in its Phase 2 trial. Is that accurate? If so, I would think that subQ Relistor would likely have a big advantage over NKTR-118 and the ultimate hope is that oral Relistor shows this similar rapid onset of action in the ongoing Phase 3 trial. It makes sense to me that a patient would likely prefer to know that they will have a bowel movement shortly after taking a drug as opposed to taking and not knowing exactly when they'll have the movement (could make for an embarrassing moment).