Biotech Values

[iwfal]

There is also a strange wildcard here. Turns out that PSA itself may have substantial impact on bone

Or, another wildcard which I think a conceptual possibility - that the drug effects bone remodeling directly. If so then there are two sub-possibilities about what that means for disease:

a) The pathway interfered with by the drug is not the same pathway that the cancer utilizes to make a home in bone. In which case the bone scans will look great - but the disease itself could still be progressing (remember, in my opinion the pain data is not (yet) all that interesting compared to, say, docetaxel.)

b) The pathway interfered with by the drug is the same one somehow exploited by PCa to make a home in bone. In which case the drug could have a great effect on bone mets while having little effect elsewhere.

If I had to pick a scenario for what the drug is doing I'd pick #a as a reasonable explanation. It would be interesting to see the bone scan data for the drug given to a mouse with a broken bone.