Biotech Values

[biomaven0]

There is also a strange wildcard here. Turns out that PSA itself may have substantial impact on bone - at least it does in gene-based in vitro testing. It principally impacts the Wnt pathway, but also appears to down-regulate CTGF, which is very likely a good thing all round. So seeing those improved bone scans all seem to be associated with increases PSA levels, maybe it is actually helping in some way.

(In the papers I have seen, people have tried to make the case that increased PSA might be partly responsible for bone mets, but they were never able to make the case, and it's conceivable that they were on the wrong track).

Peter