Biotech Values

[dewophile]

I would assume that the bone wants to heal itself - fill the void left by the tumor which it couldn't fill before because the tumor was interfering - and that would imply a hot spot flare on the bone scan

i may be out of my depth here but i think it is just the opposite - when a tumor invades bone it triggers an increase in turnover, measured as a hot spot on bone scan. when you remove the insult to bone the bone heals itself by LOWERING the rate of remodeling (my understanding is that remodeling = loss of bone, and vice vera,regardless of etiology)

Agreed that I would expect exactly that effect for bone loss in postmenopausal women. But the MOA is wildly different - it isn't about the bone healing itself but about the body actively tearing itself down which I surely wouldn't expect to be true after insult to the bone

i think the analogy is not so different. estrogen deprivation results in diffuse insult vs local insult to bone, but the idea is the same - increase turnover which in turn leads to bone loss. treating the insult, whether it is addingback estrogen or treating the local insult (e.g. tumor) reverses this leading to less rapid bone loss or even recovery of bone, which can be measured as a decrease in markers of remodeling and decrease in hot spots on bone scan