Kamada is going to start a phase I/II safety and preliminary efficacy clinical trial of its IV Alpha-1 Antitrypsin (AAT) in type 1 diabetes. A couple of more recent basic research works in the area: http://www.ncbi.nlm.nih.gov/pubmed/21099312 http://www.ncbi.nlm.nih.gov/pubmed/20692406 Baxter's Aralast is being tested by the NIAID for that indication: (looks like the trial is still in its first part (safety)) http://clinicaltrials.gov/ct2/show/NCT01183468 There is one commercial company trying to pursue the area: http://www.omnibiopharma.com/development