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Re: genisi post# 939

Tuesday, 04/08/2008 2:37:25 PM

Tuesday, April 08, 2008 2:37:25 PM

Post# of 1367
Basic science - AAT in Type 1 Diabetes:

According to a recent BBC publication (see link below), the scientists demonstrated the ability to stop the on-going destruction of insulin-producing beta cells in mice using a combination of three drugs, although they were unable to regenerate the cells. However, when they added an extra ingredient - an enzyme called Alpha 1 Antitrypsin - a significant rise in the number of beta cells was seen. The study was published in "Newscientist", not the most respectable paper out there.

http://news.bbc.co.uk/2/hi/health/7267586.stm

The effect of AAT on islet cell survival was indeed known and studied (all preclinical, just for the record):

http://www.ncbi.nlm.nih.gov/pubmed/17360983

http://www.nature.com/mt/journal/v13/n1s/abs/mt2006212a.html

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1189344


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