Perhaps sites was not the correct terminology of what i was grasping at .But you would know this better than me . I thought the viral replication process was much more complex with HIV than Hep C . Below is a quote from a very old article published in 1997 .I also remember a hepatologist telling me the Hep C virus will be easier to cure than the HIV virus due to the difference in their viral replication patterns.By no means do i know this for sure , i am asking what you think ?
"More than 20 sites within the HIV-1 protease gene have been associated with resistance to one or more of the protease inhibitors. Although each drug in this class selects for a specific, predictable pattern of genotypic changes, these patterns do overlap -- and where they do, cross-resistance may occur."