Biotech Values

[turtlepower]

ACH-1625, on the other hand, has a half-life of several days, which is suboptimal for an oral drug.

I don't remember any clinical information that directly leads to the conclusion that the half-life was several days. Slide 17 from the link below appears to indicate a half-life of a few hours for a 50mg/kg dose with the caveat that the dosing was done in rats

http://www.achillion.com/PL/pdf/1625_0905.pdf

and this is part of the conclusion of a ach-1625 presentation at EASL in april

While active uptake is an apparent mechanism for liver partitioning, the data show that < 1% of the dose remains in the liver after 24 hr post dose, indicating that elimination/redistribution of the drug occurs. There was no indication of prolonged half-life in the liver compared to plasma.

http://www.natap.org/2010/EASL/EASL_69.htm

What is the basis for your assertion that the half-life is "several days" for ACH-1625? TIA