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kei

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kei

Re: DewDiligence post# 96711

Friday, 06/04/2010 8:57:38 AM

Friday, June 04, 2010 8:57:38 AM

Post# of 257253
GETA - not many people know but GETA is also attending the ASCO

4 presentations (3 on sunday and 1 on monday)

dew .... any chance you secretly holding geta...? big smile

http://finance.yahoo.com/news/Genta-Announces-Clinical-bw-2228299311.html?x=0&.v=1

Press Release Source: Genta Incorporated On Tuesday May 4, 2010, 8:05 am EDT
BERKELEY HEIGHTS, N.J.--(BUSINESS WIRE)--Genta Incorporated (OTCBB: GETA - News) announced today that data from clinical trials of the Company's late-stage compounds, tesetaxel and Genasense® (oblimersen sodium) Injection, will be presented at the 2010 American Society of Clinical Oncology (ASCO) Annual Meeting. The meeting will be held from June 4-9, 2010 in Chicago, IL.

Highlights of the presentations include further details on the Phase 3 trials of Genasense in advanced melanoma, including a pooled analysis of early results from the AGENDA trial combined with data from Genta’s previous Phase 3 study, both of which evaluated dacarbazine chemotherapy with or without Genasense. In addition, updated results from a trial in advanced melanoma that combined Genasense plus temozolomide and Abraxane® will be presented, including data from the cohort of patients that received Genasense as a 1-hour, twice-weekly, intravenous (IV) infusion (unlike prior trials that employed a continuous IV infusion for 5-consecutive days every 3 weeks).

Updated clinical and pharmacokinetic (PK) data on tesetaxel, the leading oral taxane in clinical development, will be presented from a dose-ranging study using a once every 3-weeks schedule. The presentation will also include initial clinical and PK data from a dose-ranging study that employs a new schedule whereby the drug is administered weekly for 3 consecutive weeks, followed by 1 week off.

Titles, dates, and times of these presentations appear below.

Results of pooled analyses from two phase III trials of 1,085 patients (pts) with advanced melanoma: Oblimersen (OBL) plus dacarbazine (DTIC) versus DTIC alone. (Abstract #8573). Sunday June 6, 2010. Poster Session: Melanoma/Skin Cancers: 8 AM – 12 PM.

Relation between baseline LDH and tumor burden in advanced melanoma in two phase III trials of oblimersen-dacarbazine (OBL-DTIC) vs. DTIC. (Abstract #8557). Sunday June 6, 2010. Poster Session: Melanoma/Skin Cancers: 8 AM – 12 PM.

Oblimersen 1-hour IV infusion in combination with temozolomide and albumin-bound paclitaxel in patients with advanced melanoma. (Abstract #8561). Sunday June 6, 2010. Poster Session: Melanoma/Skin Cancers: 8 AM – 12 PM.

An inter-subject dose-escalation study of tesetaxel administered orally once every 3 weeks and once weekly for 3 consecutive weeks in patients with advanced or metastatic solid tumors. (Abstract #TPS159). Monday June 7, 2010. Poster Session: Clinical Trials, Special Session: 8 AM – 12 PM.

Phase I dose-ranging, pharmacokinetic (PK) study of tesetaxel, a novel orally active tubulin-binding agent. (Publication only).

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