Biotech Values

[mcbio]

Re: TMC435/ACHN

The phototoxicity signal with TMC435 is not new, but the existence of the trial spotted by ghmm confirms that the problem is real. You mentioned TMC435’s possible phototoxicity six months ago in #msg-43712907:

Right, I recall discussing the phototoxicity issues before. All told, the continued safety issues surrounding TMC435 bode well for ACHN and ACH-1625, and obviously the 3rd gen PIs, given that perhaps BI 201335 is now the main threat to ACH-1625 among the 2nd gen PIs. Obviously, BI 201335 is much further along.

Have there been any safety signals to date with respect to the BI compound? After taking a quick review of your links under the "Most Likely To Succeed" table, it looks like the side effects to date have been mostly attributable to peg-interferon.