The phototoxicity signal with TMC435 is not new, but the existence of the trial spotted by ghmm confirms that the problem is real. You mentioned TMC435’s possible phototoxicity six months ago in #msg-43712907:
…in looking at potential disadvantages of HCV PIs ahead of ACH-1625, [ACHN] management noted that TMC-435 compares most favorably to ACH-1625 but a presentation slide implies that TMC-435 causes billirubin elevation and has potential phototoxicity issues.
“The efficient-market hypothesis may be the foremost piece of B.S. ever promulgated in any area of human knowledge!”