It’s reasonable to infer that the second-gen protease inhibitors, VX-813 and VX-985 are effectively dead.
Why would VRTX drop the second-gen PIs? Is VRTX just naive and thinking that telaprevir can't be improved upon to a much greater degree or, what I assume, does VRTX just not believe that these two compounds do not improve upon telaprevir enough coupled with the fact that they're so far behind?