Niaspan and Intima Media thickness: DT, don't you think that this tough outcome measure would NOT be included in an interim analysis (or at least allowed to trigger a halt to the study.) If artery wall thickness is the ultimate goal of treatment and the treatment was indeed lowering LDL and raising HDL, I would imagine that the study would wait until the prescribed endpoint before an analysis of thickness.
Of course, the interim analysis might have included an artery wall thickness measure that demonstrated an INCREASE in thickness, but I would think that unlikely.
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