The insurance industry would not like having to bid competitively to participate in the Medicare coverage program for the elderly, but it is needed to protect the program and reduce costs, Obama said.
He said banks and big student lenders would not like losing their taxpayer subsidies, but it would save nearly $50 billion and make college more affordable.
And he said oil and gas companies wouldn't like losing $30 billion in tax breaks, but it was needed to fund renewable energy research.
"The system we have now might work for the powerful and well-connected interests that have run Washington for far too long, but I don't. I work for the American people," Obama said.
"I didn't come here to do the same thing we've been doing or to take small steps forward, I came to provide the sweeping change that this country demanded when it went to the polls in November."