In Roche’s long-term follow-up of 997 patients who achieved an SVR, 99.2% remained PCR negative after a mean duration of 4.1 years (<a href='read_msg.asp?message_id=19834803'>#msg-19834803</a>). I would assume that was with IFN. The question is whether the same kind of long term gain is seen with something that doesn't use the immune system. They don’t: ITMN191 is a protease inhibitor and R7128 is a polymerase inhibitor Thanks. The website had an ambiguous title that I misinterpreted.