Biotech Values

[DewDiligence]

Re: HCV cocktails

>I was somewhat surprised that both of these drugs [ITMN191 and R7128] target the same protein.<

They don’t: ITMN191 is a protease inhibitor and R7128 is a polymerase inhibitor.

>Do you know if any of the drugs used in HIV cocktails target the same protein?<

Viread and Emtriva, the two constituents of Truvada, each target reverse transcriptase.

>I am now looking into the basis of the thought that HCV is somehow eradicated (a cure) in HCV. It seems unlikely to me - e.g. Dewo's reference to HCV popping up again in 'cured' patients put on immunosuppresants…<

This is more of an academic question than a practical one. In Roche’s long-term follow-up of 997 patients who achieved an SVR, 99.2% remained PCR negative after a mean duration of 4.1 years (#msg-19834803).