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Re: iwfal post# 5562

Sunday, 03/30/2008 7:42:32 PM

Sunday, March 30, 2008 7:42:32 PM

Post# of 12660
>Not at all disingenuous - It all bears on investment approach. Before the recent rejiggering of interim and trial size I had thought about going long after the failed interim. Now that approach doesn't have legs - because of the aforementioned effect plus the overall reduced power of the trial.<

I read you load and clear (and understood exactly what you meant in your first post).

As previously noted, I think the change in the SPA is predicated on maintaining investor interest after a failed interim look. Most investors will not realize that the chance of a successful final analysis given a failed interim analysis is considerably less under the new SPA than under the old SPA. This will allow DNDN to trumpet the relatively short time interval between the interim and final analyses as a hook to keep investors from bailing en masse.

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