Dendreon Corp fka DNDNQ

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Just a note that moving of the trigger closer to the final also means that in the event that the interim is missed the ability to make it on the final goes down (compared to having the interim much earlier than the final).

This really isn't an issue for IMPACT as modeled by D9901+02a. With OBF, the nominal alpha for the final is always above .04 regardless of where the interim is. As such, the power for the final look at 360 would always be over 90%. The "apparent" issue with reduction of power remains to be the lowering of the final trigger from 360 to 304. "Apparent" because, as we discussed elsewhere, estimating power is a tricky thing where assumptions might be changed based on knowledge gained - even if we outside of DNDN might not know exactly what that knowledge was.