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Re: mhigg post# 5555

Friday, 03/28/2008 1:52:58 PM

Friday, March 28, 2008 1:52:58 PM

Post# of 12660
Therefore, by lowering the final trigger and increasing the interim trigger at the same time, the nominal alpha could become higher than before and enhancing the chance of the interim meeting stat sig.

Just a note that moving of the trigger closer to the final also means that in the event that the interim is missed the ability to make it on the final goes down (compared to having the interim much earlier than the final).

PS Note that IO found at least one case where a company thought it was obeying the OBF but clearly wasn't doing anything any of use would recognize as OBF - so I take their telephone conversation with at least some grains of salt.

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