New options for the six executive officers exercisable at $5.18 were issued on 2/22/08: Sommadossi, CEO: 350K Renaud, CFO: 80K Mayers, CMO: 80K Standring, EVP Biology: 70K Weidenbruch, Gen Counsel: 60K Fanning, SVP Human Rsrcs: 40K <a href="http://www.sec.gov/Archives/edgar/data/1093649/000120919108013219/xslF345X02/doc4.xml" target="_blank">http://www.sec.gov/Archives/edgar/data/1093649/000120919108013219/xslF345X02/doc4.xml</a> <a href="http://www.sec.gov/Archives/edgar/data/1093649/000120919108013220/xslF345X02/doc4.xml" target="_blank">http://www.sec.gov/Archives/edgar/data/1093649/000120919108013220/xslF345X02/doc4.xml</a> <a href="http://www.sec.gov/Archives/edgar/data/1093649/000120919108013223/xslF345X02/doc4.xml" target="_blank">http://www.sec.gov/Archives/edgar/data/1093649/000120919108013223/xslF345X02/doc4.xml</a> <a href="http://www.sec.gov/Archives/edgar/data/1093649/000120919108013224/xslF345X02/doc4.xml" target="_blank">http://www.sec.gov/Archives/edgar/data/1093649/000120919108013224/xslF345X02/doc4.xml</a> <a href="http://www.sec.gov/Archives/edgar/data/1093649/000120919108013221/xslF345X02/doc4.xml" target="_blank">http://www.sec.gov/Archives/edgar/data/1093649/000120919108013221/xslF345X02/doc4.xml</a> <a href="http://www.sec.gov/Archives/edgar/data/1093649/000120919108013225/xslF345X02/doc4.xml" target="_blank">http://www.sec.gov/Archives/edgar/data/1093649/000120919108013225/xslF345X02/doc4.xml</a>